Creatinine is a chemical waste molecule that is generated in blood or created by normal breakdown from the muscle metabolism, a molecule of major importance for energy production in muscles. The process of filtration of creatinine done by the kidney’s out of blood and put it in urine to leave from the body. Average 2% of the body’s creatine converted to creatinine every day and transported through the bloodstream to the kidneys. However, in cases of severe renal dysfunction, the creatinine clearance rate will be “overestimated” because the active secretion of creatinine will account for a larger fraction of the total creatinine cleared. A more complete estimation of renal function can be made when interpreting the blood (plasma) concentration of creatinine along with that of urea.
BUN-to-creatinine ratio (the ratio of urea to creatinine) can show other problems besides those intrinsic to the kidney; a urea level raised out of proportion to the creatinine may show a pre-renal problem such as volume depletion. Normally, men tend to have higher levels of creatinine because they generally have more skeletal muscle mass than women. It has also been observed that vegetarians to have lower creatinine levels too.
When the kidneys become impaired for any reason, the creatinine level in the blood will rise due to poor clearance by the kidneys, means unable to filter it properly. Abnormally high levels of creatinine thus warn of possible malfunction or failure of the kidneys. It is for this reason that standard blood tests routinely check the amount of creatinine in the blood.
The liver is responsible for the urea and passed out-of-body through urine. High values BUN can mean kidney injury or disease is present. Kidney damage caused may be because of diabetes or high blood pressure that directly affects. High BUN levels can also be caused by blockage of the urinary tract (by kidney stone or tumor) or low blood flow to the kidneys caused by dehydration or heart failure. Low values – A low BUN value is caused by a diet very low in protein, malnutrition, or severe liver damage. Drinking excessive amounts of liquid may cause dehydration and cause a low BUN value also taking diuretics, which can cause dehydration.
Early stages of kidney disease may not feel sick at all, first sign: one may be having feeling of tiredness or itchiness all over the body or frequent headaches.
If disease gets worsen, need to urinate more often or less often.
May lose your appetite, experience nausea and vomiting.
Swelling of hands or feet or may feel numb.
May get feeling of drowsiness or having trouble in concentrating.
Skin may darken and have muscle cramps.
Some people may have an incidental finding of severe kidney disease and higher creatinine on routine blood work without having any symptoms at all. In others, depending on the cause of problem, many symptoms may be present including: feeling dehydrated, fatigue, shortness of breath, confusion, or many other nonspecific symptoms.
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To your wellbeing, smile life! Enjoy.