An excess of bilirubin in blood can produce jaundice, high levels cause a yellowish discoloration of skin, tissues and sclera [the whites of eyes]. It results from an increased amount of bilirubin, a reddish-yellow pigment in blood, when bilirubin level is mildly elevated, they are yellowish and they tend to be brown when bilirubin level is high. Yellow discoloration of the skin, especially on the palms and the soles, but not of the sclera and mucous membranes (i.e. oral cavity) is due to carotenemia ~ a harmless condition important to differentiate from jaundice.
The breakdown of hemoglobin, a pigment in red blood cells forms bilirubin. The liver removes bilirubin from the blood stream and discharges it in the bile. The chemical that remains in the blood after the iron is removed becomes bilirubin. Thus, jaundice results from either excessive production of bilirubin or reduced discharge of bile though itself not a disease but a symptom of various diseases. haemolytic jaundice results from an increased breakdown of red blood cells, which causes a greater concentration of bilirubin in the blood. Hepatocellular jaundice occurs when the liver is diseased, as in hepatitis, so that it cannot secrete enough bile. Bilirubin collects in the body, resulting jaundice.
The blocking of the bile ducts causes obstructive jaundice. Gallstones may also cause such a blockage. Many babies are born with physiologic jaundice, which occurs if the body cannot process all the bilirubin it produces. In most cases, it disappears within two weeks after birth.
Bile a fluid secreted by liver helps the body digest and absorb fatty foods. It also rids the body of certain waste products. The liver secretes bile continuously, producing about 1 liter per day. Bile flows from the liver into a tube called the hepatic duct. It connects with the common bile duct, which leads to the small intestine. Except after meal most of the bile does not do directly to intestine. Rather, it enters in gall bladder, a pouch attached to the common bile duct. There, bile is stored and concentrated until needed. It contains various waste products that eventually become part of the feces (solid body wastes). One of these waste products, bilirubin, is formed from breakdown of red blood cells. Bilirubin gives bile its color, which ranges from brown to greenish-yellow. Other waste matter in the bile includes excess cholesterol and certain poisons that the liver removes from the bloodstream.
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